Brian Tomkowicz
About Brian Tomkowicz
Senior Director of Vector Engineering & Manufacturability
Brian Tomkowicz holds the position of Senior Director of Vector Engineering & Manufacturability. In this role, he oversees the development and optimization of vectors, which are critical tools in gene therapy and other biomedical applications. His work involves ensuring that these vectors can be produced efficiently and reliably at a large scale, meeting both scientific and regulatory standards.
Innate Cellular Responses and Vector Production
Brian Tomkowicz has conducted research examining the impact of innate cellular responses on vector production. His findings indicate that these cellular responses can have a detrimental effect on the efficiency of vector generation. This research is essential for understanding how to mitigate negative biological factors that hinder vector production, thereby improving overall process yields.
Testing Viral Sensitizers (VSEs)
Believing in the potential of Viral Sensitizers (VSEs), Brian Tomkowicz undertook testing to explore their impact on vector production. The rationale behind this exploration was to determine whether VSEs could counteract the negative effects of innate cellular responses, thereby enhancing vector yields and viability.
Impact of VSEs on Particle Encapsidation and Yield
During his research on Viral Sensitizers (VSEs), Brian Tomkowicz discovered that these agents significantly enhance vector production. The results showed a remarkable increase in both yield and full particle encapsidation, which were far greater than initially anticipated. This finding has important implications for the field of vector engineering, suggesting that VSEs can drastically improve production efficiency and quality.