Jacques Fantini
About Jacques Fantini
Jacques Fantini is a Professor of Biochemistry at Aix-Marseille Université, where he has worked since 1988. He is known for his research on amyloid proteins and their role in neurodegenerative diseases, particularly through the development of the chimeric peptide AmyP53, which may treat both Alzheimer's and Parkinson's diseases.
Work at Aix-Marseille University
Jacques Fantini has been a Professor of Biochemistry at Aix-Marseille Université since 1988. His tenure spans over 36 years, during which he has contributed to the academic and research environment in Marseille, France. His work focuses on biochemistry and molecular biology, particularly in relation to neurodegenerative diseases. Fantini's research has implications for understanding the molecular mechanisms underlying conditions such as Alzheimer's and Parkinson's diseases.
Education and Expertise
Jacques Fantini studied at Université de Provence, where he specialized in Biochemistry and Molecular Biology. He completed his Doctorat from 1979 to 1987, gaining extensive knowledge in the field. His academic background laid the foundation for his research in biochemistry, particularly in relation to the interactions of proteins and lipids in the brain.
Research Contributions
Fantini published a significant article in the Journal of Biological Chemistry in 2002, co-authored with Prof. Nouara Yahi. The article detailed a common sphingolipid-binding domain that facilitates the attachment of viral, bacterial, and amyloid proteins to membrane sphingolipids. He has also elucidated the biological code that governs the interaction of amyloid proteins with brain gangliosides, contributing to the understanding of neurodegenerative diseases.
Chimeric Peptide Development
Jacques Fantini collaborated with Prof. Nouara Yahi to develop a chimeric peptide known as AmyP53. This peptide has the potential to prevent the formation of calcium-permeable amyloid pores in brain cell membranes. Currently under development by AmyPore, AmyP53 is considered a promising candidate for treating both Alzheimer's and Parkinson's diseases.
Publications and Textbook Contributions
In 2015, Jacques Fantini co-authored a textbook titled 'Brain Lipids in Synaptic Function and Neurological Disease' with Prof. Nouara Yahi. This work discusses the critical role of lipids in brain function and their involvement in the pathogenesis of neurological diseases. Additionally, he has co-authored several articles on the mechanisms of oligomeric amyloid pore formation, furthering the understanding of these processes in relation to Alzheimer's and Parkinson's diseases.