Jiangchuan (Jc) Ye
About Jiangchuan (Jc) Ye
Jiangchuan (Jc) Ye is a Senior Scientist at Alltrna in Cambridge, Massachusetts, where he focuses on stem cell and cardiomyocyte research. He also works as a Research Scientist II at the Broad Institute of MIT and Harvard, developing assays for gene-targeting CRISPR screens and leading projects related to cardiovascular diseases.
Work at Alltrna
Jiangchuan Ye has been employed as a Senior Scientist at Alltrna since 2021. In this role, he operates a stem cell and cardiomyocyte platform that focuses on the maintenance of human pluripotent stem cells. He also generates transgenic cell lines utilizing CRISPR or lentiviral methods. His work contributes to advancements in cellular biology and regenerative medicine.
Current Position at Broad Institute
In addition to his role at Alltrna, Jiangchuan Ye serves as a Research Scientist II at the Broad Institute of MIT and Harvard since 2017. His responsibilities include developing medium-to-high throughput assays such as cell painting, L1000, RNA-seq, and electrophysiology. These assays are essential for conducting compound or gene-targeting CRISPR screens.
Education and Expertise
Jiangchuan Ye completed his Doctor of Medicine (MD) in Medical Clinical Sciences at Tongji University from 2004 to 2009. He further pursued a Doctor of Philosophy (PhD) in Internal Medicine with a focus on Cardiovascular Science at the same institution from 2009 to 2012. His educational background provides a strong foundation for his research in cardiology and stem cell biology.
Research Focus and Projects
Jiangchuan Ye leads target validation projects that aim to identify druggable genes associated with atrial fibrillation, fibrosis, and cardiomyopathy. He conducts genome-wide pooled CRISPR screens to investigate the interactome of atrial fibrillation-associated genes using proprietary reporter cell lines. His research is significant in understanding cardiovascular diseases and developing potential therapeutic strategies.