Paul Greback Clarke
About Paul Greback Clarke
Paul Greback Clarke is an AAV Process Development Scientist at AskBio, where he has worked since 2018. He has a background in biomanufacturing and has held various roles in gene therapy and research, including positions at Pfizer and Duke University.
Work at Asklepios BioPharmaceutical
Paul Greback Clarke has been employed at AskBio as an AAV Process Development Scientist since 2018. In this role, he has initiated R&D lab activities by cloning transgene cassettes for a lead therapeutic candidate. He has investigated novel capture and polishing methods suitable for large biomolecules. Clarke played a key role in staffing rAAV manufacturing, DNA manufacturing, R&D, analytical development, and process development during the early growth phases of AskBio's build-out. Additionally, he facilitated the development of a next-generation purification platform capable of chromatographic separation of empty and full viral particles. He also contributed to establishing analytical methods during the infancy of the Analytical Development department at AskBio.
Previous Experience in Biomanufacturing
Before joining AskBio, Paul Greback Clarke held several positions in the biomanufacturing sector. He worked as a Vector Core GMP Specialist at the University of North Carolina at Chapel Hill from 2014 to 2015. He then served as a Senior Associate Scientist in Gene Therapy at Pfizer from 2016 to 2018. During this time, he also worked at Bamboo Therapeutics, Inc. as a Manufacturing Specialist for eight months in 2016. Earlier in his career, he was a GMP Research Technician at Duke University Medical Center from 2012 to 2014.
Education and Expertise
Paul Greback Clarke earned a Bachelor of Science in Biology from the University of North Carolina at Chapel Hill, completing his studies from 2008 to 2012. He furthered his education by obtaining a Master of Science in Biomanufacturing from North Carolina State University, where he studied from 2020 to 2022. His academic background provides a solid foundation for his expertise in biomanufacturing and gene therapy.
Contributions to Gene Therapy Development
Throughout his career, Paul Greback Clarke has made significant contributions to the field of gene therapy. At AskBio, he has been involved in the development of advanced purification platforms and analytical methods, which are crucial for the production of gene therapy products. His work in cloning transgene cassettes and investigating novel methods for biomolecule capture and polishing demonstrates his commitment to advancing therapeutic candidates in the biopharmaceutical industry.