Shyam B. Karki
About Shyam B. Karki
Shyam B. Karki is the Senior Director of Drug Product Development at Bristol-Myers Squibb, with extensive experience in pharmaceutical research and development across multiple leading companies.
Current Role at Bristol-Myers Squibb
Shyam B. Karki is currently serving as the Senior Director of Drug Product Development at Bristol-Myers Squibb. Based in Summit, New Jersey, he leads the formulation design and development team, focusing on process development and scale-up. His role also involves playing a key part in the technology transfer processes, ensuring smooth transitions from discovery phases to product registration. Since the acquisition of Celgene by Bristol-Myers Squibb in November 2019, he has contributed significantly to integrating Celgene's drug product development processes into the larger framework of Bristol-Myers Squibb's operations.
Experience at Celgene
Before joining Bristol-Myers Squibb, Shyam B. Karki served as the Senior Director and Head of Pharmaceutical Science and Formulation Development at Celgene from 2016 to 2019. In this role, based in Summit, New Jersey, he was responsible for overseeing all activities related to pharmaceutical science and the formulation development of drug products. His work was pivotal in advancing Celgene's small molecule and biologics portfolios, laying the groundwork for their subsequent integration into Bristol-Myers Squibb's operations.
Background at Biogen
Shyam B. Karki gained extensive experience in small molecule drug product development during his tenure at Biogen. From 2012 to 2016, he served as the Director and Head of Small Molecule Drug Product Development in Cambridge, Massachusetts. His leadership in developing small molecule pharmaceuticals was crucial to Biogen's advancements in this domain, further solidifying his expertise in drug product development.
Career at Johnson & Johnson
Shyam B. Karki worked at Johnson & Johnson for seven years in two distinct roles. From 2010 to 2012, he was the Principal Scientist in Biologics Drug Product Development, focusing on biologics formulations. Prior to this, he served as the Director and Head of Pharmaceutical Science from 2005 to 2010, leading various initiatives in pharmaceutical research and development. His work at Johnson & Johnson contributed significantly to innovative advancements in both biologics and small molecule pharmaceuticals.
Educational Background
Shyam B. Karki holds a Ph.D. in Physical Organic Chemistry from the University of Rochester, where he studied from 1989 to 1995. He completed his undergraduate education at Davidson College, earning a Bachelor of Science degree in Chemistry from 1984 to 1988. He also attended St. Xavier's School in Kathmandu, Nepal, achieving his Cambridge O' Level from 1973 to 1983. His robust academic background laid a strong foundation for his extensive career in pharmaceutical sciences and drug product development.