Si Han Chen
About Si Han Chen
Si Han Chen is a Senior Scientist at Bristol Myers Squibb in San Diego, California, with a strong background in biophysics and biochemical sciences, and extensive research experience in the ubiquitin-proteasome system.
Current Role at Bristol Myers Squibb
Si Han Chen currently serves as a Senior Scientist at Bristol Myers Squibb in San Diego, California. In this role, he acts as a liaison between screening and disease biology groups, thereby facilitating the development of the company's portfolio. His work includes focusing on the ubiquitin-proteasome system.
Previous Experience at Genentech
Before joining Bristol Myers Squibb, Si Han Chen was a Postdoctoral Research Fellow at Genentech in South San Francisco from 2017 to 2022. During this tenure, he made a breakthrough discovery regarding the active role of proteasome-generated peptides in the efficacy of degraders and proteasome inhibitors.
Educational Background
Si Han Chen studied Biophysics at the University of California, San Francisco, earning a Doctor of Philosophy (Ph.D.) from 2009 to 2016. Prior to that, he completed a Master of Science (M.S.) in Biochemical Sciences at National Taiwan University from 2004 to 2006, and a Bachelor of Science (BSc) in Life Science at National Dong Hwa University from 2000 to 2004.
Research Experience and Focus
Si Han Chen has extensive research experience in the fields of biophysics and biochemical sciences. His research has majorly focused on the ubiquitin-proteasome system, targeting small-molecule drugs, and emerging new modalities. During his Ph.D. at UCSF, he studied viral hijacking of ubiquitin ligases and Cullin-RING ligase inter-regulation, gaining valuable mechanistic insights.
Early Research Positions
Si Han Chen has an extensive early research background. He worked at Academia Sinica, Taiwan, in various roles including Assistant Researcher and M.Sc. Student in the Shih-Hsiung Wu Laboratory from 2004 to 2009. He also engaged in undergraduate research from 2002 to 2004 in Lou-Sing Kan Laboratory. Additionally, he held Ph.D. lab rotation positions at UCSF in the Matt Jacobson Laboratory and Yifan Cheng Laboratory in 2010 and 2009 respectively.