Xin Xu
About Xin Xu
Xin Xu is a scientist at Bristol Myers Squibb in Redwood City, California, with a PhD in Biochemistry, Biophysics, and Molecular Biology from Kansas State University.
Current Role at Bristol Myers Squibb
Xin Xu is currently employed as a Scientist at Bristol Myers Squibb, based in Redwood City, California, United States. Their role involves advanced scientific research and development within the pharmaceutical industry. The position likely includes various tasks related to biochemical analysis, molecular biology, and protein structure research.
Work Experience at Kansas State University
Xin Xu served as a Graduate Research Assistant and Graduate Teaching Assistant at Kansas State University in Manhattan, Kansas, United States. The Graduate Research Assistant role, held from 2019 to 2021, involved significant research responsibilities in the fields of biochemistry and molecular biology. Prior to this, from 2017 to 2019, Xin Xu worked as a Graduate Teaching Assistant, supporting academic instruction and assisting students in their learning processes.
Educational Background and PhD Achievement
Xin Xu completed a Doctor of Philosophy (PhD) degree in Biochemistry, Biophysics, and Molecular Biology at Kansas State University from 2017 to 2021. During this period, Xin Xu acquired substantial knowledge and expertise in these scientific areas, contributing to various research projects and achieving significant academic milestones.
Protein Expression and Purification Techniques
Xin Xu successfully expressed the human complement protein factor H (fH) using HEK 293 and freestyle F 293 cells. They purified the protein through size exclusion and affinity columns by employing tangential flow filtration and GE Akta fast protein liquid chromatography. These advanced methodologies are critical for obtaining high-purity proteins for further biochemical analysis.
Surface Plasmon Resonance and Crystallography
Utilizing Biacore T200 surface plasmon resonance, Xin Xu identified the minimal binding partner within fH and Beta C protein, a Group B Streptococcal surface protein. Additionally, they optimized Beta C protein crystals using techniques such as Crystal Phoenix protein crystallization robot and manual hangover drops, and subsequently shot crystals through Argonne National Lab. Xin Xu built crystal structure models with a resolution of 2.36 Å using Phenix and Pymol.
Publications and Mentoring
Xin Xu has authored ten peer-reviewed publications, including five first-author papers, with one featured on the cover and top reads of the issue. They have also mentored new graduate students, helping them acclimate and feel comfortable in the lab environment. Xin Xu’s experience in mentoring illustrates their dedication to fostering a collaborative and supportive research environment.