Yucheng Mu
About Yucheng Mu
Yucheng Mu is a scientist at Bristol Myers Squibb in Cambridge, Massachusetts, with a PhD in Chemistry from Boston College and a BS in Chemistry from Nanjing University.
Title
Yucheng Mu is a Scientist currently working at Bristol Myers Squibb in Cambridge, Massachusetts, United States.
Previous Roles
Yucheng Mu served as a Research Assistant at Boston College from 2016 to 2021. Prior to that, he worked at Nanjing University as a Research Assistant from 2014 to 2016.
Education and Expertise
Yucheng Mu holds a Doctor of Philosophy (PhD) in Chemistry from Boston College, where he studied from 2016 to 2021. Additionally, he earned a Bachelor of Science (BS) in Chemistry from Nanjing University, where he studied from 2012 to 2016.
Stereoselective Total Synthesis of Dolabelide C
Yucheng Mu completed the first stereoselective total synthesis of dolabelide C, a potent cytotoxic natural product against HeLa cell lines. This synthesis involved 19 linear steps and 39 steps in total.
Developing Catalytic Ring-Closing Metathesis (RCM)
Yucheng Mu developed a method for the stereoselective synthesis of E- and Z-trisubstituted macrocyclic alkenes through catalytic ring-closing metathesis (RCM).
Advances in Catalytic Cross-Metathesis (CM)
He pioneered the stereoselective synthesis of E- and Z-trisubstituted alkenyl fluorides through catalytic cross-metathesis (CM). This work was noted for its application in peptide synthesis using E- and Z-alkenyl fluorides as amide bond mimics.
Contributions to Bio-Active Molecule Synthesis
Yucheng Mu enabled the concise synthesis of more than five bio-active molecules. He achieved this through the development of E- and Z-, Di- and trisubstituted alkenyl nitrile synthesis via catalytic cross-metathesis.
Broadly Applicable Olefin Metathesis Technique
Mu developed a broadly applicable olefin metathesis technique that can be used at a multi-gram scale without a glove box. This technique tolerates free alcohols and carboxylic acids through an in-situ protection strategy.