Zuoning Han
About Zuoning Han
Zuoning Han is a Senior Research Investigator at Bristol-Myers Squibb in Hopewell, NJ, with a background in immunology and extensive experience in drug and biomarker development.
Company
Zuoning Han currently works at Bristol-Myers Squibb as a Senior Research Investigator at their Hopewell, NJ location. His previous roles include Principal Research Investigator at Sanofi in Bridgewater, NJ from 2010 to 2012, Senior Scientist at Aventis in Bridgewater, NJ from 2001 to 2005, Project Scientist at UC San Diego in San Diego, California from 1995 to 2001, and Visiting Scholar at The Scripps Research Institute in San Diego, California from 1994 to 1995.
Title
Zuoning Han holds the title of Senior Research Investigator at Bristol-Myers Squibb. In this capacity, he has contributed significantly to the field of biomedical research, particularly in understanding and treating renal and lung fibrosis.
Education and Expertise
Zuoning Han earned his Doctor of Philosophy (Ph.D.) in Immunology from Beijing University between 1991 and 1994. He also has a Master's degree in Microbiology & Immunology from XIAN University, completed from 1985 to 1988. Furthermore, he holds a Doctor of Medicine (MD) degree from Ningxia Medical University, which he earned from 1978 to 1983. His academic background forms a solid foundation for his extensive research career.
Developed Biomarker Assays
Zuoning Han has developed various biomarker assays for kidney and lung fibrosis. These include assays for cytokine, collagen, a-SMA, smad phosphorylation, fibronectin, and active PAI-1. His work in this area has been critical in advancing understanding and treatment of fibrotic conditions.
Established Drug Targets and In Vitro Assays
At Bristol-Myers Squibb, Han proposed and established a DP0 drug target specifically for renal fibrosis. Additionally, he has created in vitro assays using human kidney epithelial cells (RPTEC) and human lung fibroblasts (MRC-5), enriching the tools available for fibrosis research and drug development.
Research and Model Development
Han has created ex-vivo and in vivo models to support biomarker and drug function studies. His notable contributions include whole blood assays for mouse and human samples and acute in vivo models such as the LPS model and TGF model. These models provide essential insights into the efficacy of therapeutic interventions.
Presented Research to Senior Management
Zuoning Han has presented his research data at senior management meetings at Bristol-Myers Squibb. His presentations have been instrumental in guiding research directions and decision-making processes within the company.