Sarah Elisabeth Pierce
About Sarah Elisabeth Pierce
Biology researcher with strong interests in genetic engineering, high-throughput CRISPR screening, and single-cell sequencing. As a PhD student at Stanford University in Will Greenleaf and Monte Winslow's labs, I developed a method to combine high-throughput CRISPR screening with a single-cell epigenomic read-out (Spear-ATAC; Pierce*, Granja*, et al Nature Communications 2021, https://www.nature.com/articles/s41467-021-23213-w). I also uncovered a novel role for the tumor suppressor liver-kinase B1 (LKB1) in modulating the chromatin accessibility states of non-small cell lung cancer primary tumors and metastases, with implications for the early detection of metastatic samples (Pierce*, Granja*, et al Nature Cell Biology 2021, https://www.nature.com/articles/s41556-021-00728-4). Finally, I helped to develop and validate new ways of performing CRISPR screens in 3D spheroids compared to 2D culture (Han*, Pierce, et al Nature 2020 https://www.nature.com/articles/s41586-020-2099-x). As a postdoc in David Liu’s lab, I am currently working on projects related to genetic engineering and protein evolution. I look forward to connecting with you!