Sean Hofherr
About Sean Hofherr
Sean Hofherr is a Senior Director at Broad Clinical Labs, where he leads clinical strategy and product development. He has extensive experience in genetics, having held various leadership roles at organizations such as GeneDx and Mayo Clinic, and he holds a PhD in Molecular and Human Genetics from Baylor College of Medicine.
Work at Broad
Sean Hofherr serves as the Chief Clinical Strategy and Product Development at Broad Clinical Labs, a role he has held since 2024. He has been with the Broad Institute of MIT and Harvard as a Senior Director for the same duration, contributing to the organization's mission in clinical genomics. His responsibilities include overseeing clinical strategies and product development, focusing on advancing genomic research and its applications in healthcare.
Previous Experience at GeneDx
Before joining Broad, Sean Hofherr held multiple positions at GeneDx. He served as Executive Vice President from 2020 to 2022 and as Chief Scientific Officer from 2017 to 2020. In these roles, he was instrumental in driving the company's strategic direction and scientific initiatives. Additionally, he worked as the CLIA Laboratory Director at GeneDx from 2018 to 2022, overseeing laboratory operations and compliance.
Education and Expertise
Sean Hofherr earned his Doctor of Philosophy (PhD) in Molecular and Human Genetics from Baylor College of Medicine, where he studied from 2002 to 2008. He also holds a Bachelor of Science in Microbiology and Cell Science from the University of Florida, obtained between 1997 and 2002. His expertise includes newborn screening and laboratory genetics, underscored by his status as a Board Certified Laboratory Geneticist and a Fellow of the American College of Medical Genetics.
Background in Clinical Genetics
Sean Hofherr has a robust background in clinical genetics, having worked at the Mayo Clinic in various capacities. He completed a Clinical Molecular Genetics Fellowship from 2011 to 2012 and a Clinical Biochemical Genetics Fellowship from 2009 to 2011. His earlier role as a Research Fellow at the Mayo Clinic from 2008 to 2009 further solidified his foundation in genetics research and clinical applications.
Leadership Roles in Healthcare
In addition to his roles at Broad and GeneDx, Sean Hofherr served as the Chief Operating Officer and Clinical Director at Fabric Genomics from 2022 to 2024. He also held leadership positions at Children's National Health System, where he was the Director of Biochemical Genetics and Metabolism, as well as the Director of Molecular Diagnostics from 2012 to 2017. His leadership experience spans various aspects of clinical genetics and genomics.