Darren Hsu
About Darren Hsu
Darren Hsu is a Postdoctoral Research Associate at Oak Ridge National Laboratory, specializing in theoretical and biophysical chemistry. He has a background in developing AI models for protein-ligand interactions and has held various academic and research positions at Northwestern University and AstraZeneca.
Work at Oak Ridge National Laboratory
Darren Hsu has been serving as a Postdoctoral Research Associate at Oak Ridge National Laboratory since 2021. In this role, he is involved in advanced research initiatives, contributing to the laboratory's mission of scientific discovery and innovation. His work focuses on developing methodologies that enhance the understanding of molecular interactions and structural biology.
Education and Expertise
Darren Hsu holds a Bachelor of Science (B.S.) in Theoretical Chemistry from National Taiwan University, where he studied from 2011 to 2015. He further pursued a Ph.D. in Biophysical Chemistry at Northwestern University from 2015 to 2020. His educational background equips him with a strong foundation in theoretical and experimental approaches in chemistry and molecular dynamics.
Previous Research Experience
Before his current position, Darren Hsu worked as a Postdoctoral Fellow at AstraZeneca for six months in 2020-2021. He also served as a Research Assistant and Ph.D. Candidate at Northwestern University from 2015 to 2020, where he developed a high-throughput workflow for induced-fit docking of ligands. His experience includes significant contributions to research safety initiatives and teaching roles.
Innovative Projects and Contributions
Darren Hsu has developed a first-in-class transformer-based AI model designed to predict the bound structures of proteins and ligands. He is currently focused on developing X-ray scattering-based pose retrieval methods that integrate crystallographic refinement with molecular dynamics simulations. These projects highlight his commitment to advancing computational techniques in chemistry.
Involvement in Academic Initiatives
During his time at Northwestern University, Darren Hsu was actively involved in the Academics for Careers in Data Science (ACiDS) student group from 2019 to 2020. He also participated in the Research Safety Student Initiative (RSSI) from 2018 to 2020, demonstrating his engagement in both academic and safety-focused initiatives within the research community.