Anna Marie Pyle
About Anna Marie Pyle
Anna Marie Pyle is a Sterling Professor at Yale University and a founder and advisor at RIGImmune Inc. She has extensive experience in RNA research and has held various advisory and leadership roles in scientific organizations.
Work at Yale University
Anna Marie Pyle has served as a Sterling Professor at Yale University since 2002. Her role involves leading research initiatives and mentoring students in the field of biochemistry and molecular biology. Pyle's research group focuses on understanding the interactions between large RNA tertiary structures and proteins, as well as small molecules. This position has allowed her to contribute significantly to the academic community in New Haven, CT, for over two decades.
Current Roles and Advisory Positions
In addition to her position at Yale University, Anna Marie Pyle is actively involved in several advisory roles. She has been a Scientific Advisory Board Member at SomaLogic since 2021 and previously served on the Scientific Advisory Board of Arrakis Therapeutics from 2016 to 2023. Pyle also holds a position as a Founder and Advisor at RIGImmune Inc. since 2020. Furthermore, she has been a member of the Science and Technology Steering Committee at Brookhaven National Laboratory since 2013.
Education and Expertise
Anna Marie Pyle completed her Bachelor's degree in Chemistry at Princeton University from 1981 to 1985. She then pursued a Doctor of Philosophy (PhD) in Chemistry at Columbia University, graduating in 1989. Pyle furthered her education with a Postdoctoral Fellowship in Biochemistry at the University of Colorado Boulder from 1990 to 1992. Her extensive educational background has equipped her with expertise in biophysical methods, crystallography, enzymology, and microscopy.
Research Focus and Contributions
Pyle's research primarily investigates the mechanisms by which motor proteins are activated by RNA. This includes studying viral replicative proteins, such as HCV NS3, and innate immune receptors like RIG-I. Her research group employs a variety of techniques to explore large RNA tertiary structures and their recognition by proteins and small molecules. Pyle's contributions to the field are documented on her dedicated website, www.pylelab.org, which features her projects and publications.
Leadership Roles in Scientific Organizations
Anna Marie Pyle has held significant leadership positions in scientific organizations. She served as President of The RNA Society from 2019 to 2021, where she contributed to advancing the understanding of RNA research. Her involvement in these organizations reflects her commitment to fostering collaboration and innovation within the scientific community.