InVivo Biosystems
InVivo Biosystems provides comprehensive services to accelerate research and innovation for pharmaceutical, nutraceutical, biotechnology companies, and academic institutions, specializing in custom genome-edited C. elegans and zebrafish models, preclinical CRO services, and advanced disease modeling.
Services
InVivo Biosystems offers an extensive array of services aimed at accelerating research and innovation for pharmaceutical, nutraceutical, biotechnology companies, and academic institutions. Key services include in vivo model creation, toxicity studies, phenotype screening, target identification and validation, and lead optimization. They also provide high throughput screening using automated analysis with sensitive behavioral, morphological, and fluorescent assays. The company specializes in providing preclinical CRO services to bridge the data gap between cell culture and rodent models, enabling rapid preclinical studies to de-risk clinical trials.
C. elegans and Zebrafish Models
InVivo Biosystems is adept at creating custom genome-edited C. elegans and zebrafish models, utilized for basic research and disease modeling. The C. elegans services include custom injection, CRISPR knockout, CRISPR knock-in, array line, MosSCI services, as well as strain maintenance and storage services. For zebrafish, the offerings encompass CRISPR knockout, CRISPR knock-in, Tol2 transgenesis services, injection mix, and Crispants services. Additionally, they provide humanization services such as whole gene humanization and point mutation humanization.
Preclinical CRO Services
The company provides comprehensive preclinical CRO services designed to support drug discovery and development. Their services include RapidGen platform, zebrafish toxicity testing, neurotoxicity analysis, antioxidant capacity study, global gene expression, mitochondrial function study, vitality study, efficacy testing, microbiome study, and advanced aging and longevity services. These services help bridge the data gap between cell culture and rodent models and offer insights necessary for preclinical studies and drug discovery to de-risk clinical trials or decide the next phase of product development.
Disease Modeling Services
InVivo Biosystems offers specialized disease modeling services to study conditions such as epilepsy, Parkinson's, neurodegenerative diseases, Alzheimer's disease, and COVID-19. These models aid in understanding disease mechanisms and developing potential treatments. The company also provides humanized models which are essential for accurately simulating human disease conditions to study pathologies and assess drug efficacy.
Omics and Phenotyping Analysis
The company provides comprehensive omics-based analysis, including transcriptomics, proteomics, metabolomics, and genomics. They utilize automated phenotyping platforms and machine learning for deep phenotyping services, which include lifetime vitality measurement, Kaplan Meier survival curve quantification, healthspan measurement, mitochondrial function study, protein aggregation study, and sarcopenia analysis. These services help determine the effects of compounds on maintaining healthy aging and muscle function.