One Codex
One Codex is a healthcare IT company based in San Francisco, specializing in microbiome sequencing and analysis with a focus on the gut microbiome, utilizing a cloud-based platform to meet various regulatory and compliance requirements.
Company Overview
One Codex, based in San Francisco, CA, specializes in healthcare IT, particularly in microbiome sequencing and analysis services. The company is part of the Y-Combinator S14 batch and has a team of 16 employees. One Codex offers comprehensive microbial genomics solutions, including a cloud-based analytical platform for metagenomic sample analysis.
Microbiome Sequencing and Analysis Services
One Codex provides microbiome sequencing and analysis services optimized for the gut microbiome. Their offerings include shotgun sequencing with results available in as little as four weeks. They utilize fully automated DNA extraction processes and library prep methods that minimize GC bias. Sample kits ensure reproducibility and traceability from the lab to analysis results. Sequenced libraries are processed for taxonomic resolution down to the species and strain levels.
Cloud-Based Analytical Platform
One Codex leverages a cloud-based analytical platform to support microbial genomics research. This platform accommodates regulatory and compliance requirements, including GxP and HIPAA. It integrates capabilities for sequencing, health record data tracking, and interactive visualization, making it suitable for various clinical metagenomics workflows. The platform also supports secure data sharing and collaboration, enabling independent research by team members.
Microbial Genomics Reference Database
One Codex maintains a microbial genomics reference database with over 115,000 whole microbial reference genomes. This database allows for accurate analysis of complex metagenomic samples, filtering raw classification results through statistical post-processing to eliminate false positives. Researchers can access the Genome Library for one-click assembly, genome annotation browsing, and real-time querying of genomic sequences.
Sequencing Depth Calculator
One Codex offers a sequencing depth calculator to assist researchers in determining the appropriate number of sequencing reads needed to detect organisms of interest. This tool is designed to optimize sequencing depth, ensuring comprehensive detection and characterization of microbial genomes. It supports the company's goal of accelerating microbiome discovery workflows and ensuring reproducibility in clinical trials.