PMV Pharmaceuticals
Founded in 2013, PMV Pharmaceuticals focuses on developing small-molecule therapies targeting specific genetic alterations with a tumor-agnostic approach. Their lead product, rezatapopt, is a selective p53 reactivator undergoing clinical trials for advanced solid tumors.
History of PMV Pharmaceuticals
PMV Pharmaceuticals was founded in 2013 with a focus on the discovery and development of small-molecule therapies aimed at specific genetic alterations. Headquartered in Princeton, NJ, the company has built a precision oncology platform leveraging over four decades of research experience. PMV Pharma's innovative approach involves physically correcting the precise geometry of mutant p53 proteins to restore their wild-type function.
Small-Molecule Therapies by PMV Pharmaceuticals
PMV Pharmaceuticals specializes in developing small-molecule therapies that target specific genetic alterations. The company's tumor-agnostic approach aims to address various forms of cancer. PMV Pharma's lead product candidate, rezatapopt (PC14586), is a first-in-class selective reactivator of p53, targeting the p53 Y220C mutation. Rezatapopt is currently undergoing clinical trials for patients with advanced solid tumors, both as a standalone treatment and in combination with pembrolizumab.
Rezatapopt Clinical Trials
Rezatapopt (PC14586), PMV Pharma's lead product candidate, is in clinical trials for patients with advanced solid tumors. This orally available small molecule is designed to reactivate the p53 Y220C mutation, which is the ninth most frequent p53 mutation and is observed in at least 30 different tumor types. The U.S. FDA has granted Fast Track designation to rezatapopt for treating locally advanced or metastatic solid tumors with this specific mutation.
PMV Pharmaceuticals Headquarters
PMV Pharmaceuticals is headquartered at 1 Research Way, Princeton, NJ 08540. The company offers a dynamic, diverse, and state-of-the-art work environment. Located in Princeton, NJ, which is ranked #2 in best places to live in NJ by Niche.com, PMV Pharma promotes a family-first environment while fostering innovation.
PMV Pharmaceuticals' Work Environment
PMV Pharmaceuticals ensures a dynamic and innovative work environment that emphasizes diversity and state-of-the-art facilities. The company offers highly competitive salaries and benefits, encouraging a family-first approach. PMV Pharma fosters an atmosphere conducive to research and development, allowing employees to thrive while contributing to groundbreaking cancer therapies.