Surrozen
Surrozen is pioneering targeted regenerative antibodies to repair tissues and restore organs damaged by serious diseases, with a focus on severe alcoholic hepatitis and other conditions.
Services
Surrozen focuses on developing targeted regenerative antibodies to repair damaged tissues and restore organ function. They leverage their proprietary technology platforms, SWAP (Wnt-mimetics) and SWEETS (R-spondin-mimetics), to activate and enhance the body's biological repair mechanisms. Their platform aims to overcome current limitations of regenerative medicine by designing tissue-specific antibodies.
Products
Surrozen's lead program is SZN-043, targeting severe alcoholic hepatitis. SZN-043 has shown potential to stimulate hepatocyte regeneration, improve liver function, and reduce fibrosis in chronic liver injury models. The company also has a pipeline of disease-specific antibodies for multiple areas, including retinal disorders and pulmonary diseases.
Technology Platforms
Surrozen employs two primary technology platforms: SWAP and SWEETS. The SWAP technology activates Wnt signaling by binding specific Fzd and Lrp receptors, while SWEETS enhances the body's response to endogenous Wnt protein by stabilizing Frizzled receptors. These platforms play a crucial role in developing therapeutics aimed at tissue regeneration.
Research and Development
Surrozen's research focuses on diseases affecting the liver, eye, and lung. SZN-043, targeting severe alcoholic hepatitis, has shown proof-of-concept by improving liver function and reducing fibrosis in chronic liver injury models. Their antibody-based Wnt mimetics have shown promise in treating corneal endothelial dystrophies and dry eye disease. Preclinical models indicate potential for treating pulmonary fibrosis through decreased inflammation and improved lung function.
Location and Benefits
Surrozen is headquartered at The Cove at Oyster Point in South San Francisco, which offers amenities such as a café, dining hall, lounge, full-service bar, indoor and outdoor fire pits, and various sports and extracurricular activities. Employee benefits include medical, dental, vision, life insurance, short-term disability, and a 401(k) retirement plan.